An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the activity of sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming), EC 1.1.1.153, which plays an important part in the biosynthesis of tetrahydrobiopterin.
ChEBI ID: 74234
| Member | Definition | Class | Studies | Trials |
|---|---|---|---|---|
| sulfadiazine | A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position. | pyrimidines; | 12,712 | 624 | |
| sulfamethoxazole | An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position. | sulfonamide; | 23,252 | 2,720 | |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| interleukin 8 | Homo sapiens (human) | Potency | 66.8242 | 1 | 1 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 0.6682 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 23.9185 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 54.4372 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 30.2788 | 3 | 3 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 11.9856 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 13.3332 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 43.2397 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 30.7051 | 2 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 6.9111 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.1778 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| exodeoxyribonuclease V subunit RecD | Escherichia coli str. K-12 substr. MG1655 | IC50 | 106.4380 | 2 | 2 |
| exodeoxyribonuclease V subunit RecB | Escherichia coli str. K-12 substr. MG1655 | IC50 | 106.4380 | 2 | 2 |
| exodeoxyribonuclease V subunit RecC | Escherichia coli str. K-12 substr. MG1655 | IC50 | 106.4380 | 2 | 2 |
| Aurora kinase A | Homo sapiens (human) | IC50 | 21.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| ATP-dependent 6-phosphofructokinase | Trypanosoma brucei brucei | IC50 | 57.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 422.6667 | 3 | 6 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 12.7203 | 1 | 3 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 12.7203 | 1 | 3 |
| Dihydropteroate synthase | Escherichia coli K-12 | IC50 | 4.7000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 4.7000 | 1 | 1 |
| Dihydrofolate reductase | Pneumocystis carinii | IC50 | 0.1000 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | IC50 | 12.7203 | 1 | 3 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | IC50 | 223.3333 | 3 | 3 |
| Protease | Human immunodeficiency virus 1 | Ki | 0.0101 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Protein-arginine deiminase type-4 | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Protease | Human immunodeficiency virus 1 | Kd | 0.5770 | 1 | 1 |
| Studies | Pre-1990 | 1990's | 2000's | 2010's | Post-2020 |
|---|---|---|---|---|---|
| 8,224 | 5,291 | 676 | 587 | 1,079 | 591 |